The results are yet to be published but a clinical trial has been completed by emory university and anecdotally there were very promising results. Clarithromycin is often used for pneumonia, bronchitis, and. Clarithromycin is the generic form of the brandname prescription drug biaxin, an antibiotic used to treat bacterial infections. Clarithromycin mechanisms in hypersomnia syndromes full. Subjects could not have moderate or severe sleep apnea, severe periodic limb movement disorder with arousals, metabolic disorders thought to explain their hypersomnia symptoms, hypocretin deficiency, or cataplexy.
Further evaluation of this novel therapy is needed. A study of clarithromycin in the treatment of gabarelated hypersomnia indicates that this drug may be effective in some patients with idiopathic hypersomnia ih, narcolepsy without cataplexy, and subjective hypersomnia. Clarithromycin oral tablet biaxin is used to prevent and treat certain bacterial infections. Secondary endpoints will include a decrease in pvt lapses and changes in epworth, stanford, and fosq sleep scales. Improvement in daytime sleepiness with clarithromycin in patients with gabarelated hypersomnia. Lynn marie trotti, md the term hypersomnia describes a group of symptoms that includes severe daytime sleepiness and sleeping long periods of time more than 10 hours per night. Find patient medical information for clarithromycin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This was a fiveweek, randomized, placebocontrolled, doubleblind, crossover trial of clarithromycin 500 mg with breakfast and lunch, in patients with hypersomnolence syndromes excluding narcolepsy with cataplexy and evidence for abnormal cerebrospinal fluid potentiation of gabaa receptors. Learn about side effects, warnings, dosage, and more.
Summary of research into clarithromycin as a hypersomnia. Use effective birth control to prevent pregnancy while you are using this medicine. Clarithromycin may be useful in the treatment of hypersomnia associated with enhancement of gabaa receptor function. Take this medication by mouth with food as directed by your doctor, usually once daily. Gaba is known to promote sleep and decreased consciousness, and many patients with cns hypersomnia have been found to have endogenous gabaa receptor hyperreactivity. The investigators therefore propose a pilot, crossover trial comparing clarithromycin to placebo for the treatment of hypersomnia in patients with excess gabaa potentiation. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Antibiotic may decrease eds in gabarelated hypersomnia. Clarithromycin for the treatment of hypersomnia full.
Clarithromycin responders were significantly younger than nonresponders. Clinical experience article in journal of psychopharmacology 287 december 20 with 125 reads. Asking your doctor about clarithromycin have you been reading some of the articles on the web about the benefits of clarithromycin for people with idiopathic hypersomnia. The primary endpoint will be a decrease in pvt reaction time. However, it is not known whether these effects would occur in humans. Summary of research into clarithromycin as a hypersomnia treatment.
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